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DPP9 inhibitor

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SI-7377

DPP9 inhibitor, >98% (HPLC)

CAS No. : [3020859-03-1]

IUPAC Name : tert-Butyl ((1s,3r,5R,7S)-3-((2-(5,6-difluoroisoindolin-2-yl)-2-oxoethyl)amino)adamantan-1-yl)carbamate

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Chemical Properites
Mol. Formula :
C25H33F2N3O3
Mol. Weight :
461.55
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This selectively inhibits DPP9 with low‑nanomolar potency (IC50 = 3 nM) and shows substantially weaker inhibition of DPP8 (IC50 = 0.6 µM). It induces dose‑dependent LDH release in THP‑1 cells, making it a useful tool for probing DPP9‑regulated cell death pathways.

References : Benramdane S. et al.: J. Med. Chem., 66(18), 12717-12738, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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