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Droxidopa impurity M

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Droxidopa impurity M, >98%

CAS No. : [90044-46-5]

Synonyms : (±)-Tetrahydroxy pavinane

IUPAC Name : 5,6,11,12-Tetrahydro-5,11-epiminodibenzo[a,e][8]annulene-2,3,8,9-tetraol

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Chemical Properites
Mol. Formula :
C16H15NO4
Mol. Weight :
285.3
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Droxidopa, which is an orally active norepinephrine precursor that raises standing blood pressure and relieves orthostatic hypotension symptoms. Droxidopa is being studied for neurogenic orthostatic hypotension (nOH) and as a potential alternative for ADHD treatment.

References : Horacio K. et al.: Neurology, 83(4), 328-335, 2014; Dela Pena I. et al.: Eur. J. Pharmacol., 892, 173826, 2021; Cao L. F. et al. Neural Plast. 2016, 6383240, 2016; Kaufmann H. Clin Auton Res., 18 Suppl 1, 19-24, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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