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DS-1971a

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SI-7648

DS-1971a, >98% (HPLC)

CAS No. : [1450595-86-4]

IUPAC Name : 5-Chloro-2-fluoro-4-(((1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl)oxy)-N-(pyrimidin-4-yl)benzenesulfonamide

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Chemical Properites
Mol. Formula :
C20H21ClFN5O3S
Mol. Weight :
465.93
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : DS‑1971a selectively inhibits NaV1.7 with nanomolar potency in both human and mouse channels (IC50 = 22.8–59.4 nM). Its strong functional activity translates into significant analgesic effects, supporting its use in NaV1.7‑dependent pain research.

References : Shinozuka T. et al.: J. Med. Chem., 63(18), 10204-10220, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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