DYRK2 inhibitor

SI-7293

DYRK2 inhibitor, >98% (HPLC)

IUPAC Name : (6-((4-(Benzo[d]thiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)pyridin-3-yl)(piperazin-1-yl)methanone

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a highly potent DYRK2 inhibitor discovered through virtual screening and subsequent structural optimization. It exhibits sub‑nanomolar DYRK2 potency (IC₅₀ = 0.6 nM) and demonstrates exceptional kinase selectivity across a 205‑kinase panel. Structural insights from the DYRK2–43 cocrystal clarify its tight, specific binding mode. It also shows excellent water solubility (29.5 mg/mL), favorable safety (LD₅₀ > 10,000 mg/kg), and strong anti‑prostate‑cancer activity, positioning it as a promising preclinical DYRK2‑targeted therapeutic candidate.

References : Yuan K. et al.: J. Med. Chem., 66(6), 4215-4230, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.