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(E)-Olopatadine hydrochloride

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(E)-Olopatadine hydrochloride, >98%

CAS No. : [949141-22-4]

Synonyms : trans-Olopatadine hydrochloride

IUPAC Name : (E)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid hydrochloride

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Chemical Properites
Mol. Formula :
C21H23NO3 . HCl
Mol. Weight :
373.88
Appearance :
Off-white solid (hygroscopic)
Melting Point :
Not available
Solubility :
H2O
For Laboratory research use only, not for drug, household or other uses.

Applications : (E)-Olopatadine is a less stable form or an impurity of the (Z)-Olopatadine, which is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis.

References : Kam K. W. et al.: Ocul Immunol Inflamm., 25(5), 663-677, 2017; Leonardi A. et al.: Expert Opin Pharmacother., 11(6), 969-81, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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