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(E/Z)-Zotiraciclib hydrochloride

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SI-6336

(E/Z)-Zotiraciclib hydrochloride, >98% (HPLC)

CAS No. : [1321626-25-8]

Synonyms : (E/Z)-TG02 hydrochloride; (E/Z)-SB1317 hydrochloride

IUPAC Name : (E)-6-Methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene hydrochloride

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Chemical Properites
Mol. Formula :
C23H24N4O • HCl
Mol. Weight :
408.93
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (E/Z)-Zotiraciclib hydrochloride is a strong orally active inhibitor of CDK2, JAK2, and FLT3, demonstrating IC50 values in the 13–73 nM range. By blocking key proliferative signaling pathways, it effectively inhibits cancer cell growth and serves as a valuable tool in cancer research.

References : William A. D. et al.: J. Med. Chem., 55(1), 169-196, 2012; Pasha M. K. et al.: Drug Metab. Lett., 6(1), 33-42, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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