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Eganelisib

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SI-5330

Eganelisib, >98% (HPLC)

CAS No. : [1693758-51-8]

MDL No. : MFCD30533720

Synonyms : IPI-549

IUPAC Name : (S)-2-Amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Properites
Mol. Formula :
C30H24N8O2
Mol. Weight :
528.58
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Eganelisib is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM. Eganelisib shows >100-fold selectivity over other lipid and protein kinases. Eganelisib has potential for the treatment of cancer.

References : Evans C. A. et al.: ACS Med Chem Lett., 7(9), 862-867, 2016; De Henau O. et al.: Nature 539(7629), 443-447, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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