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EGFR inhibitor

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SI-7556

EGFR inhibitor, >98% (HPLC)

CAS No. : [2103339-34-8]

IUPAC Name : (R)-1-(3-(4-Amino-3-(3-chloro-4-((6-methylpyridin-2-yl)methoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one

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Chemical Properites
Mol. Formula :
C26H26ClN7O2
Mol. Weight :
503.99
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an analog of Ibrutinib, which is a covalent, irreversible BTK inhibitor that blocks B‑cell receptor signaling by targeting Cys481 in the BTK active site. It shows high potency, broad activity across B‑cell malignancies, and is clinically approved for CLL, MCL, WM, and other B‑cell cancers. Its covalent mechanism delivers sustained BTK inhibition, driving anti‑proliferative and pro‑apoptotic effects in malignant B cells.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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