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Elimusertib

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SI-7576

Elimusertib, >98% (HPLC)

CAS No. : [1876467-74-1]

Synonyms : BAY-1895344

IUPAC Name : (R)-3-Methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

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Chemical Properites
Mol. Formula :
C20H21N7O
Mol. Weight :
375.44
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Elimusertib selectively inhibits ATR with nanomolar potency (IC50= 7 nM) and displays robust antitumor efficacy. Its activity across solid tumor and lymphoma models makes it a valuable tool for probing ATR‑regulated DNA repair pathways and therapeutic vulnerabilities.

References : Luecking T. U. et al.: Cancer Research., 77(13), 2017; Wengner M. A. et al.: Cancer Research, 77(13), 2017; Lucking U. et al.: J. Med. Chem., 63(13), 7293-7325, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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