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Elubrixin hydrochloride

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SI-5123

Elubrixin hydrochloride, >98% (HPLC)

CAS No. : [688763-65-7]

Synonyms : SB-656933 hydrochloride

IUPAC Name : 1-(4-Chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea hydrochloride

Price And Availability
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5MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Back Order  Estimated to ship on 04 October 2026
We accept
Note: Elubrixin hydrochlorideis not in stock but can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and Mass analysis. Purity (HPLC) is usually >98%. COA, QC data and SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or Request A Quote. We respond promptly. Thank You!
Chemical Properites
Mol. Formula :
C17H17Cl2FN4O4S . HCl
Mol. Weight :
499.76
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Elubrixin is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation.

References : Mozaffari S. et al.: Expert Opin Investig Drugs 24(7), 949-956, 2015; Lazaar A. L. et al.: Br. J. Clin Pharmacol., 72(2), 282-293, 2011; Nicholson G. C. et al.: Pulm Pharmacol Ther., 20(1), 52-59, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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