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Emavusertib phosphate

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SI-6350

Emavusertib phosphate, >98% (HPLC)

CAS No. : [2376399-38-9]

Synonyms : CA-4948 phosphate

IUPAC Name : (R)-N-(5-(3-Hydroxypyrrolidin-1-yl)-2-morpholinooxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide phosphate

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C24H25N7O5 • H3PO4
Mol. Weight :
589.5
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Emavusertib phosphate is an orally active inhibitor of IRAK4 and FLT3 that disrupts NF‑κB/MyD88 signaling and reduces IL‑6 and IL‑10 levels. These activities contribute to its anti‑inflammatory profile and its ability to inhibit tumor‑cell proliferation and induce apoptosis. It shows robust antitumor efficacy in vivo.

References : Wiese M. D. et al.: Expert. Opin. Investig. Drugs, 1-8, 2020; Guidetti F. et al.: J. Clin. Med., 12(2), 399, 2023; Parrondo R. D. et al.: Front Immunol., 14, 1239082, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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