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SI-6109

Emricasan, >98% (HPLC)

CAS No. : [254750-02-2]

Synonyms : PF 03491390; IDN-6556

IUPAC Name : (S)-3-((S)-2-(2-((2-(Tert-butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

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Chemical Properites
Mol. Formula :
C26H27F4N3O7
Mol. Weight :
569.51
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Emricasan functions as an irreversible pan‑caspase inhibitor with oral activity. It prevents ZIKV‑triggered increases in caspase‑3 activity and protects human cortical neural progenitors from virus‑induced apoptosis.

References : Gracia-Sancho J. et al.: Hepatol. Commun., 3(7), 987-1000, 2019; Barreyro F. J. et al.: Liver Int., 35(3), 953-66, 2015; Hoglen. N. C. et al.: J Pharmacol. Exp. Ther., 309(2), 634-40, 2004; McCall M. et al.: Surgery, 150(1), 48-55, 2011; Tian J. et al.: Transl Stroke Res., 9(4), 382-392, 2017; Xu M. et al.: Nat. Med., 22(10), 1101-1107, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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