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Enasidenib

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SI-5453

Enasidenib, >98% (HPLC)

CAS No. : [1446502-11-9]

MDL No. : MFCD29472245

Synonyms : AG-221

IUPAC Name : 2-Methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol

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We accept
Chemical Properites
Mol. Formula :
C19H17F6N7O
Mol. Weight :
473.38
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively. Enasidenib medication is used to treat relapsed or refractory acute myeloid leukemia.

References : Shih H. A. et al.: Blood 124, 437, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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