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Encorafenib

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SI-5253

Encorafenib, >98% (HPLC)

CAS No. : [1269440-17-6]

MDL No. : MFCD25976758

Synonyms : LGX818

IUPAC Name : Methyl (S)-(1-(4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)propan-2-yl)carbamate

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We accept
Chemical Properites
Mol. Formula :
C22H26ClFN6O4S
Mol. Weight :
525.00
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Encorafenib is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM). Encorafenib is used to treat unresectable or metastatic melanoma with specific mutations.

References : Li Z. et al.: Cancer Lett., 370(2), 332-44, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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