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Entacapone EP impurity E

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SL-4973

Entacapone EP impurity E, >98%

CAS No. : [7659-29-2]

MDL No. : MFCD00069263

IUPAC Name : 3,5-Dinitrobenzene-1,2-diol

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Chemical Properites
Mol. Formula :
C6H4N2O6
Mol. Weight :
200.11
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Entacapone (Entacapone EP impurity E), which is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinson's disease as an adjunct to Levodopa and Carbidopa therapy.

References : De Santi C. et al.: Eur J. Clin Pharmacol, 54(3), 215-219, 1998; .Di Giovanni S. et al.: J Biol Chem, 285(20), 14941-14954, 2010; Jenner P. et al.: Neurology, 62(1 Suppl 1), S47-55, 2004; Hamaue N. et al. Brain Res, 1309, 110-115, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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