Entrectinib

SI-2651

Entrectinib, >98% (HPLC)

CAS No. : [1108743-60-7]

MDL No. : MFCD28129099

Synonyms : RXDX101; RXDX 101; RXDX-101; NMS E628; NMS-E628

IUPAC Name : N-(5-(3,5-Difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
Note: Entrectinib is not in stock but can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and Mass analysis. Purity (HPLC) is usually >98%. COA, QC data and SDS will be provided along with the product. For information on pricing and availability please contact us atsales@syninnova.com or Request A Quote. We respond promptly. Thank You!

Applications : Entrectinib is a potent and orally available Trk, ROS1, and ALK inhibitor; inhibits TrkA, TrkB, TrkC, ROS1 and ALK with IC₅₀ values of 1, 3, 5, 12 and 7 nM, respectively.

References : Menichincheri M. et al.: J. Med. Chem., 59(7), 3392-3408, 2016; Ardini E. et al.: Mol Cancer Ther., 15(4), 628-639, 2016; Rolfo C. et al.: Expert Opin Investig Drugs. 24(11),1493-1500, 2015; Russo M. et al.: Cancer Discov. 6(1), 36-44,2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.