EP4 antagonist 14

SI-7925

EP4 antagonist 14, >98% (HPLC)

CAS No. : [3035217-40-1]

IUPAC Name : 4-((2-(4-(Trifluoromethyl)benzyl)-2H-indazole-3-carboxamido)methyl)benzoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a single‑nanomolar EP4 antagonist with high subtype selectivity and strong drug‑like properties. It suppresses PGE₂‑driven immunosuppressive gene expression and, when dosed orally, delivers potent antitumor immunity—both alone and in combination with anti‑PD‑1—highlighting its promise as a next‑generation EP4‑targeted immunotherapy lead.

References : Cheng Z. et al.: J. Med. Chem., 66(9), 6218-6238, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.