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Epetraborole

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SI-7390

Epetraborole, >98% (HPLC)

CAS No. : [1093643-37-8]

Synonyms : GSK-2251052; AN-3365

IUPAC Name : (S)-3-(Aminomethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol

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Chemical Properites
Mol. Formula :
C11H16BNO4
Mol. Weight :
237.06
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Epetraborole targets leucyl‑tRNA synthetase with submicromolar potency (IC50 = 0.31 µM), thereby inhibiting protein synthesis in bacteria. Its activity profile supports its use in research on multidrug‑resistant Gram‑negative infections.

References : Goldstein E. J. et al.: Antimicrob. Agents Chemother., 57(5), 2401-4, 2013;O'Dwyer K. et al.: Antimicrob. Agents Chemother., 59(1), 289-98, 2015; Sutcliffe J. A. Ann N. Y. Acad. Sci., 1241, 122-52, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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