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Epetraborole hydrochloride

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SI-7391

Epetraborole hydrochloride, >98% (HPLC)

CAS No. : [1234563-16-6]

Synonyms : GSK-2251052 hydrochloride; AN-3365 hydrochloride

IUPAC Name : (S)-3-(Aminomethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

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Chemical Properites
Mol. Formula :
C11H16BNO4 • HCl
Mol. Weight :
273.52
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Epetraborole hydrochloride inhibits LeuRS with submicromolar potency (IC50 = 0.31 µM), thereby disrupting aminoacyl‑tRNA formation and protein synthesis. It is applied in research focused on multidrug‑resistant Gram‑negative pathogens.

References : Goldstein E. J. et al.: Antimicrob. Agents Chemother., 57(5), 2401-4, 2013;O'Dwyer K. et al.: Antimicrob. Agents Chemother., 59(1), 289-98, 2015; Sutcliffe J. A. Ann N. Y. Acad. Sci., 1241, 122-52, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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