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Eplerenone EP impurity A

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Eplerenone EP impurity A, >98%

CAS No. : [209253-67-8]

Synonyms : 3-Oxo-17α-pregn-4-ene-7α,9:21,17-dicarbolactone; Pregn-4-ene-7,21-dicarboxylic acid, 9,17-dihydroxy-3-oxo-,di-γ-lactone, (7α,17α); Pregn-4-ene-7,21-dicarboxylic acid, 9,17-dihydroxy-3-oxo-,7,9: 21,17-dilactone, (7α,17α)

IUPAC Name : (2R,7'R,8'R,9'R,10'S,13'S,14'S)-10',13'-Dimethyl-1',3,4,7',8',10',11',12',13',14',15',16'-dodecahydro-2'H,5H-spiro[furan-2,17'-[9,7](epoxymethano)cyclopenta[a]phenanthrene]-3',5,19'(6'H)-trione

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Chemical Properites
Mol. Formula :
C23H28O5
Mol. Weight :
384.47
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Eplerenone (Eplerenone EP impurity A), which is a mineralocorticoid receptor antagonist, and blocks the action of aldosterone, used to control high blood pressure.

References : Kobayashi N. et al.: Hypertension 45(4), 538-544, 2005; Keidar S. et al.: J. Cardiovasc Pharmacol., 41(6), 955-963, 2003; Ward M. R. et al.: Circulation 104(4), 467-472, 2001; Suzuki G. et al.: Circulation 106(23), 2967-2972, 2002; Lacolley P. et al.: Circulation 106(22), 2848-2853, 2002.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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