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Eplerenone EP impurity B

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Eplerenone EP impurity B, >98%

CAS No. : [192704-82-8]

Synonyms : 11α,12α-Epoxy-7α-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

IUPAC Name : Methyl (1R,3aS,3bS,4R,9aR,9bS,9cS,10aR,10bR)-9a,10b-dimethyl-5',7-dioxo-2,3,3a,3b,4,4',5,5',7,8,9,9a,9b,9c,10a,10b-hexadecahydro-3'H-spiro[cyclopenta[1,2]phenanthro[3,4-b]oxirene-1,2'-furan]-4-carboxylate

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Chemical Properites
Mol. Formula :
C24H30O6
Mol. Weight :
414.50
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Eplerenone (Eplerenone EP impurity B), which is a mineralocorticoid receptor antagonist, and blocks the action of aldosterone, used to control high blood pressure.

References : Kobayashi N. et al.: Hypertension 45(4), 538-544, 2005; Keidar S. et al.: J. Cardiovasc Pharmacol., 41(6), 955-963, 2003; Ward M. R. et al.: Circulation 104(4), 467-472, 2001; Suzuki G. et al.: Circulation 106(23), 2967-2972, 2002; Lacolley P. et al.: Circulation 106(22), 2848-2853, 2002.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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