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Eragidomide

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SI-6156

Eragidomide, >98% (HPLC)

CAS No. : [1860875-51-9]

Synonyms : CC-90009

IUPAC Name : 2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

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Chemical Properites
Mol. Formula :
C22H18ClF2N3O4
Mol. Weight :
461.85
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Eragidomide is a GSPT1‑selective cereblon modulator that acts as a molecular glue, redirecting the CRL4^CRBN ubiquitin ligase complex to promote GSPT1 ubiquitination and degradation. Its high selectivity makes it a valuable tool for probing GSPT1 biology and CRBN‑dependent degradation pathways.

References : Surka C. et al.: Blood, 137(5), 661-677, 2021; Hansen D. J. et al.: J. Med. Chem., 64(4), 1835-1843, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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