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ERW-1041E

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SI-8164

ERW-1041E, >98% (HPLC)

CAS No. : [918440-87-6]

IUPAC Name : Quinolin-3-ylmethyl (S)-2-((((S)-3-bromo-4,5-dihydroisoxazol-5-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Properites
Mol. Formula :
C20H21BrN4O4
Mol. Weight :
461.32
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : ERW-1041E irreversibly inhibits TG2 with a Ki of 11 µM and shows high target specificity. Its irreversible binding mode supports its application in studies of TG2‑dependent signaling, fibrosis, and inflammatory pathways.

References : Dafik L. et al.: PLoS One, 7(2), e30642, 2012; Penumatsa K. C. et al.: Am J. Physiol. Lung Cell Mol. Physiol., 313(5), L752-L762, 2017; Watts R. E. et al.: J. Med. Chem., 49(25), 7493-501, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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