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Esreboxetine

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SI-6153

Esreboxetine, >98% (HPLC)

CAS No. : [98819-76-2]

Synonyms : (S,S)-(+)-Reboxetine

IUPAC Name : (S)-2-((S)-(2-Ethoxyphenoxy)(phenyl)methyl)morpholine

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Chemical Properites
Mol. Formula :
C19H23NO3
Mol. Weight :
313.4
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Esreboxetine is the (S,S)-isomer of Reboxetine and a selective norepinephrine reuptake inhibitor that elevates urethral resistance. Clinical data show benefit in stress urinary incontinence, achieved through increased urethral closure. Its pharmacology involves NET inhibition across central and peripheral systems, with peripheral selectivity contributing to its pronounced urethral effects while minimizing CNS exposure.

References : Fleishaker J. C. et al.: Biopharm. Drug Dispos., M 20(1), 53-7, 1999; Herman B. D. et al.: Clin. Pharmacol. Ther., 66(4), 374-9, 1999.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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