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Etoposide impurity 1

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SL-10585

Etoposide impurity 1, >98%

CAS No. : [23363-35-1]

IUPAC Name : (5R,5aR,8aR,9S)-5-(4-Hydroxy-3,5-dimethoxyphenyl)-9-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one

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Chemical Properites
Mol. Formula :
C27H30O13
Mol. Weight :
562.52
Appearance :
Solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version an impurity of Etoposide. This can be used as an analytical labelled reference standard. Etoposide is an anti-cancer chemotherapeutic agent that acts by inhibiting topoisomerase II, thereby preventing DNA replication. Etoposide promotes cell cycle arrest, apoptosis, and autophagy in treated cells.

References : Lee K I. et al.: Toxicol In Vitro., S0887-2333(16), 30147-3, 2016; Calvani M. et al.: Oncotarget., 7(32), 51138-51149, 2016; Fuchs J. et al.: Cancer 83(11), 2400-7, 1998; Hande K. R. et al. Oncologist., 1(4), 234-239, 1996; Cui D. et al. Cell Rep., 30(2), 497-509.e4, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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