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Etrasimod

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SL-11859

Etrasimod, >98%

CAS No. : [1206123-37-6]

Synonyms : APD334

IUPAC Name : (R)-2-(7-((4-Cyclopentyl-3-(trifluoromethyl)benzyl)oxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

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Chemical Properites
Mol. Formula :
C26H26F3NO3
Mol. Weight :
457.49
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Etrasimod is a potent, selective, and orally bioavailable antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor, exhibiting an IC50 value of 1.88 nM in CHO cells. It is being developed as a next-generation therapeutic agent for the treatment of multiple sclerosis (MS) and other autoimmune disorders.

References : Buzard D. J. et al.: ACS Med Chem Lett., 5(12), 1313-1317, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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