EXEL-0346

SI-6989

EXEL-0346, >98% (HPLC)

CAS No. : [1239893-96-9]

IUPAC Name : N-((S)-1-((1R,3R,5S)-3-Amino-8-azabicyclo[3.2.1]octan-8-yl)-3-(4-bromophenyl)-1-oxopropan-2-yl)-1-(4-(trifluoromethoxy)phenyl)cyclopropane-1-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : EXEL‑0346 functions as a highly potent oral GCS inhibitor (IC₅₀ = 2 nM). It synergizes with insulin to increase pAkt signaling and robustly decreases glycosphingolipids including GlcCer, LacCer, and GM3. These biochemical effects translate into significant improvements in metabolic dysfunction, obesity, and diabetes.

References :
Richards S. et al.: J. Med. Chem., 55(9), 4322-35, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.