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Ezetimibe-d4

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SL-7791

Ezetimibe-d4, >98% (CP)

Isotopic Purity : 98 atom % D

CAS No. : [1093659-90-5]

Synonyms : SCH-58235-d4

IUPAC Name : (3R,4S)-1-(4-Fluorophenyl-2,3,5,6-d4)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

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Chemical Properites
Mol. Formula :
C24H17D4F2NO3
Mol. Weight :
413.46
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ezetimibe-d4 is a deuterium labelled version an analog of Ezetimibe, which is a potent, selective, cholesterol absorption inhibitor, used to lower cholesterol. This can be used as an internal reference standard.

References : Clader J. W. et al.: J. Med Chem., 47(1), 1, 2004; During A. et al.: J. Nutr, 135(10), 2305, 2005; Davis H. R Jr. et al.: Arterioscler Thromb Vasc Biol, 21(12), 2032, 2001; Delaney W. E 4th, et al. Antimicrob Agents Chemother, 50(7), 2471, 2006; van Heek M. et al.: Br. J. Pharmacol., 134(2), 409, 2001; Davis H. R. et al.: J. Atheroscler Thromb., 14(3), 99, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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