EZH2 inhibitor

SI-6408

EZH2 inhibitor, >98% (HPLC)

IUPAC Name : 8-Bromo-5-chloro-6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-2-((1-(hydroxymethyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This pyridone‑derived EZH2 inhibitor demonstrates that phosphate prodrugging is an effective medicinal‑chemistry solution for overcoming the intrinsic solubility limitations of pyridone scaffolds. The phosphate prodrug shows rapid and efficient in vivo conversion, high systemic exposure of the active parent, and strong antitumor activity in a DLBCL Karpas‑422 xenograft, validating the strategy as broadly applicable to insoluble pyridone‑based EZH2 inhibitors.

References : Kung P-P. et al.: J. Med. Chem., 64(3), 1725−1732, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.