EZH2 inhibitor

SI-6409

EZH2 inhibitor, >98% (HPLC)

IUPAC Name : (3-((8-Bromo-5-chloro-6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-4,6-dimethyl-2-oxopyridin-1(2H)-yl)methyl dihydrogen phosphate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a pyridone‑derived phosphate prodrug engineered to overcome the poor aqueous solubility of its EZH2‑inhibitor parent SI-6408. It shows efficient in vivo conversion, high systemic exposure, and strong tumor‑growth inhibition in a DLBCL xenograft model—demonstrating that phosphate prodrugging is a broadly useful strategy for insoluble pyridone‑based EZH2 inhibitors.

References : Kung P-P. et al.: J. Med. Chem., 64(3), 1725−1732, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.