Fasudil hydrochloride

SI-6293

Fasudil hydrochloride, >98% (HPLC)

CAS No. : [105628-07-7]

Synonyms : HA-1077 hydrochloride; AT-877 hydrochloride

IUPAC Name : 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride

Price And Availability
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1G	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : Fasudil hydrochloride inhibits ROCK1/2 with sub‑micromolar potency and also suppresses PKA, PKC, and PKG at micromolar concentrations. Beyond its nonspecific kinase activity, it serves as a potent Ca²⁺ channel antagonist and produces marked vasodilation, supporting its use in vascular biology and RhoA/ROCK‑dependent signaling research.

References : Chen M. et al.: Expert Opin. Investig. Drugs.,22(4), 537-50, 2013; Huang X. N. et al.: J. Neuroimmunol., 239(1-2), 61-7, 2011; Uehata M. et al.: Nature., 389(6654), 990-4, 1997; Fukushima M. et al.: Liver Int. 25(4), 829-38, 2005; Zhang J. et al.: Clin. Chim. Acta., 401(1-2), 76-80, 2009; Sun X. et al.: J. Neuroimmunol., 180(1-2), 126-34, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.