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Felodipine EP impurity A

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Felodipine EP impurity A, >98%

Related CAS No. : [96382-71-7] of the free base compound

Synonyms : Dehydro felodipine hydrochloride

IUPAC Name : 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate hydrochloride

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Chemical Properites
Mol. Formula :
C18H17Cl2NO4 . HCl
Mol. Weight :
418.70
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Felodipine (Felodipine EP impurity A), which is a long-acting 1,4-dihydropyridine calcium channel blocker, used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

References : Johnson J. D. et al.: J. Pharmacol Exp Ther., 226(2), 330-334, 1983; Rodler S. et al.: J. Mol Cell Cardiol., 27(10), 2295-2302, 1995; Yiu S. et al.: J. Med Chem., 39(23), 4576-4582, 1996; Ding Y. et al.: Hypertension 32(4), 718-723, 1998; Yang Z. et al.: Cardiovasc Res., 53(1), 227-231, 2002; Perez-Reyes E. et al.: J. Pharmacol Exp Ther., 328(2), 621-627, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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