FGFR inhibitor (S)-23

SI-7551

FGFR inhibitor (S)-23, >98% (HPLC)

IUPAC Name : (S)-N-(3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-inden-5-yl)-4-fluoro-3-((5-methoxypyridin-3-yl)ethynyl)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent FGFR inhibitor with GI₅₀ values of 6.4–10.4 nM across multiple FGFR‑driven cancer models. It shows broad activity against FGFR1–4 alterations, has favorable PK and low DDI risk, and delivers near‑complete tumor suppression with 99.1% TGI at 10 mg/kg in MFE‑296 xenografts, supporting its potential for FGFR‑mutant cancers.

References : Ding W. et al.: J. Med. Chem., 67(4), 2941-2962, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.