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Fisogatinib

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SI-7066

Fisogatinib, >98% (HPLC)

CAS No. : [1707289-21-1]

Synonyms : BLU-554

IUPAC Name : N-((3S,4S)-3-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide

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Chemical Properites
Mol. Formula :
C24H24Cl2N4O4
Mol. Weight :
503.38
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Fisogatinib is a potent and selective FGFR4 inhibitor (IC50 = 5 nM) with favorable oral activity. It exhibits marked anti‑tumor effects in hepatocellular carcinoma models reliant on FGFR4 signaling.

References : Dogan-Topal B. et al.: J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 1110-1111, 116-123, 2019; Richard K. et al.: E. J. C., Volume 69, Supplement 1, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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