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Fluorometholone acetate

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SL-10637

Fluorometholone acetate, >98%

CAS No. : [[3801-06-7]]

IUPAC Name : (6S,8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl acetate

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Chemical Properites
Mol. Formula :
C24H31FO5
Mol. Weight :
418.51
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research.

References : Kupferman A. et al.: Arch Ophthalmol., 100(4), 640-1, 1982; Zuhal A. et al.: Chem Biol Drug Des., 86(4), 857-63, 2015; Leibowitz M. H. et al.: Ann Ophthalmol., 16(12), 1110-5, 1984.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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