Flupirtine-d4 hydrochloride

SI-7656

Flupirtine-d₄ hydrochloride, >98% (HPLC)

CAS No. : [1324717-75-0]

Synonyms : D-9998-d₄ hydrochloride

IUPAC Name : Ethyl (2-amino-6-((4-fluorophenyl-2,3,5,6-d₄)methylamino)pyridin-3-yl)carbamate hydrochloride

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : Flupirtine‑d₄ hydrochloride is a deuterium labelled version of Flupirtine hydrochloride, suitable for pharmacokinetic and mechanistic studies. The parent compound is a BBB‑penetrant non‑opioid analgesic that activates Kv7 channels, antagonizes NMDA receptors, and enhances GABAergic tone. It strengthens BBB integrity, reduces oxidative and inflammatory stress, promotes vascular‑neuronal recovery, and suppresses pathological calcium influx. These combined actions stabilize neuronal excitability and protect against excitotoxic, ischemic, and cytokine‑mediated injury, supporting its use in diverse neurodegenerative and pain research models.

References : Russak E. M. et al.: Ann. Pharmacother., 53(2), 211-216, 2019; Kornhuber J. et al.: J. Neural. Transm. (Vienna), 106(9-10), 857-67, 1999.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.