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Fluzoparib

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SI-7072

Fluzoparib, >98% (HPLC)

CAS No. : [1358715-18-0]

Synonyms : Fuzuloparib; SHR-3162

IUPAC Name : 4-(4-Fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one

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Chemical Properites
Mol. Formula :
C22H16F4N6O2
Mol. Weight :
472.4
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Fluzoparib potently inhibits PARP1 with sub‑nanomolar activity and demonstrates strong antitumor efficacy. It selectively targets HR‑deficient cells and increases the sensitivity of diverse cell types to cytotoxic agents. Its robust pharmacokinetic profile supports its application in BRCA1/2‑mutant ovarian cancer research.

References :
Lei W. et al.: Cancer Sci. 110(3), 1064-1075, 2019; Huiping L. et al.: Chin. J. Cancer Res. 32(3), 370-382, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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