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FMF-04-159-2

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SI-7824

FMF-04-159-2, >98% (HPLC)

CAS No. : [2364489-81-4]

Synonyms : AKOS-04

IUPAC Name : (E)-N-(1-((3-(4-(Dimethylamino)but-2-enamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide

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Chemical Properites
Mol. Formula :
C28H30Cl3N7O5S
Mol. Weight :
683.01
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : FMF‑04‑159‑2 covalently inhibits CDK14 with an IC50 of 39.6 nM and shows secondary activity against CDK2 (IC50 = 256 nM) in NanoBRET assays. This profile supports its use in studies of CDK14‑regulated cell‑cycle and signaling processes.

References : Ferguson M. F. et al.: Cell. Chem. Biol., 26(6), 804-817, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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