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FN-1501-propionic acid

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SI-7785

FN-1501-propionic acid, >98% (HPLC)

CAS No. : [2408642-48-6]

IUPAC Name : 4-(4-(4-(4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-1H-pyrazole-3-carboxamido)benzyl)piperazin-1-yl)-4-oxobutanoic acid

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Chemical Properites
Mol. Formula :
C25H27N9O4
Mol. Weight :
517.55
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : FN‑1501‑propionic acid serves as a warhead for PROTAC development, providing selective engagement of CDK2 and CDK9. Coupling this ligand to a CRBN E3‑ligase binder yields the bifunctional degrader HY‑130709, which targets CDK2/9 for proteasomal degradation.

References : Zhou F. et al.: Eur. J. Med. Chem., 187, 111952, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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