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Foretinib

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SI-6445

Foretinib, >98% (HPLC)

CAS No. : [849217-64-7]

Synonyms : GSK-1363089; GSK-089; EXEL-2880; XL-880

IUPAC Name : N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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100MGRequest A Quote
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250MGRequest A Quote
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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C34H34F2N4O6
Mol. Weight :
632.66
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Foretinib potently inhibits MET (IC50 = 0.4 nM) and KDR (IC50 = 0.9 nM), providing broad blockade of oncogenic and angiogenic signaling pathways. It is widely used in research on tumor proliferation, invasion, and vascularization.

References : Qian F. et al.: Cancer Res., 69(20), 8009-8016, 2009. Kataoka Y. et al.: Invest. New Drugs, 2011; Eder J. P. et al.: Clin. Cancer Res., 16(13), 3507-3516, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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