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Fosbretabulin disodium

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SI-6702

Fosbretabulin disodium, >98% (HPLC)

CAS No. : [168555-66-6]

Synonyms : Combretastatin A4 disodium phosphate; CA 4DP; CA 4P

IUPAC Name : Sodium (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl phosphate

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Chemical Properites
Mol. Formula :
C18H19Na2O8P
Mol. Weight :
440.3
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Fosbretabulin disodium, the disodium salt of the Combretastatin A4 proagent, destabilizes tubulin and selectively targets tumor endothelial cells. It collapses newly formed tumor vasculature, decreases blood flow, and induces central necrosis within solid tumors.

References : Shen C. H. et al.: Br. J. Pharmacol., 160(8), 2008-27, 2010; Pettit G. R. et al.: J. Med. Chem., 48(12), 4087-99, 2005; Tozer G. M. et al.: Cancer Res., 59(7), 1626-34, 1999.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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