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Fosdevirine

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SI-5917

Fosdevirine, >98% (HPLC)

CAS No. : [1018450-26-4]

Synonyms : GSK-2248761; IDX-899

IUPAC Name : Methyl (R,E)-(2-carbamoyl-5-chloro-1H-indol-3-yl)(3-(2-cyanovinyl)-5-methylphenyl)phosphinate

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Chemical Properites
Mol. Formula :
C20H17ClN3O3P
Mol. Weight :
413.80
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Fosdevirine is a highly potent anti-HIV non-nucleoside reverse transcriptase (NNRT) inhibitor, developed for the potential treatment of HIV-AIDS. But now it has been discontinued due to unexpected side effects.

References : Dousson C. et al.: J. Med. Chem., 59(5), 1891-1898, 2016; Margolis D. A. et al.: Antivir Ther., 19(1), 69-78, 2014; Olgen S. Mini Rev Med Chem.,13(12), 1700-8, 2013; Castellino S. et al.: Chem Res Toxicol., 26(2), 241-51, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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