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Fostamatinib

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SI-5241

Fostamatinib, >98% (HPLC)

CAS No. : [901119-35-5]

MDL No. : MFCD16628163

Synonyms : R788

IUPAC Name : (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate

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Chemical Properites
Mol. Formula :
C23H26FN6O9P
Mol. Weight :
580.47
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Fostamatinib is the oral prodrug of the active compound Tamatinib, which is an orally available and competitive Syk/FLT3 inhibitor. Tamatinib is a potential drug for treatment of the inflammation associated with and causing bronchial asthma resulting from allergen-induced airway hyperresponsiveness (AHR).

References : McAdoo P. S. et al.: Drugs Future 36(4), 273,2011; Sylvia Braselmann S. et al.: J. Pharmacol Exp Ther., 319(3), 998-1008, 2006; Hoon-Suk Cha et al.: J. Pharmacol Exp Ther., 317(2), 571-578, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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