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FPR2 agonist 2

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SI-7030

FPR2 agonist 2, >98% (HPLC)

CAS No. : [2829263-20-7]

IUPAC Name : (S)-1-(3-(4-Cyanophenyl)-1-(5-fluoroindolin-1-yl)-1-oxopropan-2-yl)-3-(4-fluorophenyl)urea

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Chemical Properites
Mol. Formula :
C25H20F2N4O2
Mol. Weight :
446.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This functions as a potent, brain‑penetrant FPR2 agonist (EC50 = 0.13 µM; FPR1 = 1.1 µM). It attenuates inflammatory cytokine release, stabilizes mitochondrial function, and suppresses caspase‑3 activity, making it a valuable tool compound for probing FPR2‑dependent anti‑inflammatory pathways.

References : Mastromarino M. et al.: J. Med. Chem., 65(6), 5004-5028, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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