FRAX - 486

SI-7191

FRAX - 486, >98% (HPLC)

CAS No. : [1232030-35-1]

IUPAC Name : 6-(2,4-Dichlorophenyl)-8-ethyl-2-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : FRAX486 selectively inhibits PAK1, PAK2, and PAK3 with low‑nanomolar potency (IC₅₀ = 14/33/39 nM), making it a valuable tool for studying PAK‑mediated cellular processes and downstream signaling.

References : Wang Y. et al.: PLoS One, 11(4), e0153312, 2016; Hayashi-Takagi A. et al.: Proc. Natl. Acad. Sci. U S A., 111(17), 6461-6, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.