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FRM-024

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SI-6789

FRM-024, >98% (HPLC)

CAS No. : [2085780-87-4]

IUPAC Name : (5R,6S)-5-(4-Chlorophenyl)-6-cyclopropyl-3-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-5,6-dihydro-4H-1,2,4-oxadiazine

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Chemical Properites
Mol. Formula :
C22H22ClN5O2
Mol. Weight :
423.9
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : FRM‑024 is an orally active γ‑secretase modulator with robust CNS penetration, capable of reducing Aβ42 levels. It serves as a valuable tool for investigating γ‑secretase–dependent APP processing in familial Alzheimer’s disease models.

References : Bursavich M. G. et al.: J. Med. Chem., 64(19), 14426-14447, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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