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Fulvestrant 3-β-D-glucuronide

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SL-9491

Fulvestrant 3-β-D-glucuronide, >98%

CAS No. : [261506-27-8]

IUPAC Name : (2S,3S,4S,5R)-3,4,5-Trihydroxy-6-(((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

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Chemical Properites
Mol. Formula :
C38H55F5O9S
Mol. Weight :
782.90
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a glucoronide metabolite of Fulvestrant, which is a pure antiestrogen and a potent estrogen receptor (ER) antagonist. It is also a GPR30 agonist. It also induces autophagy and has antitumor efficacy.

References : Wakeling A. E. et al.: Cancer Res., 51(15), 3867-73, 1991; Yu X. et al.: Mol Cancer 14, 208, 2015; Osborne C. K. et al.: Br. J. Cancer 90 Suppl 1, S2-6, 2004; Garner F. et al.: Anticancer Drugs 26(9), 948-56, 2015; Julia K. et al.: Eur. J. Neurosci., 27(7), 1700-9, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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