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Furosemide acyl β-D-glucuronide

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Furosemide acyl β-D-glucuronide, >98%

CAS No. : [72967-59-0]

Synonyms : Furosemide glucuronide

IUPAC Name : (2R,3R,4R,5S)-6-((4-Chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

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Chemical Properites
Mol. Formula :
C18H19ClN2O11S
Mol. Weight :
506.86
Appearance :
Yellow solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a glucuronide metabolite of Furosemide, which is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.

References : Charak B. S. et al.: J. Antimicrob Chemother, 27(1), 95-104, 1991; Wiemer G. et al.: J. Pharmacol Exp Ther., 271(3), 1611-1615, 1994; .Gutschmidt K. U. et al.: Neuroscience, 91(4), 1471-1481, 1999; Shiozaki A. et al.: J. Physiol Sci., 56(6), 401-406, 2006; Olsen S. C. et al. Am J. Vet Res., 53(5), 742-747, 1992.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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