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FXIa-IN-19 dihydrochloride

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SI-5652

FXIa-IN-19 dihydrochloride, >98% (HPLC)

CAS No. : [2413219-66-4]

IUPAC Name : Methyl ((5R,9S)-9-(1-(3-chloro-2-fluorophenyl)-5-methyl-1H-imidazole-4-carboxamido)-5-methyl-4-oxo-3-aza-1(4,2)-pyridina-2(1,2)-benzenacyclononaphane-24-yl)carbamate dihydrochloride

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Chemical Properites
Mol. Formula :
C31H30ClFN6O4 . 2HCl
Mol. Weight :
677.98
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a potent, orally bioavailable pyridine-based macrocyclic FXIa inhibitor. Moreover, this pyridinebased macrocycle, possessing the phenylimidazole carboxamide P1, exhibited excellent selectivity against relevant blood coagulation enzymes and displayed antithrombotic efficacy in a rabbit thrombosis model.

References : Corte R. J. et al.: J. Med. Chem., 63(20), 784-803, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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