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Ganaplacide

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SI-5530

Ganaplacide, >98% (HPLC)

CAS No. : [1261113-96-5]

MDL No. : MFCD28502124

Synonyms : KAF156; GNF156

IUPAC Name : 2-Amino-1-(2-(4-fluorophenyl)-3-((4-fluorophenyl)amino)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethan-1-one

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Chemical Properites
Mol. Formula :
C22H23F2N5O
Mol. Weight :
411.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ganaplacide is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite.

References : Kuhen K. L. et al.: Antimicrob Agents Chemother., 58(9), 5060-5067, 2014;
Leong F. J. et al.: Antimicrob Agents Chemother., 58(11), 6437-6443, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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